Part 1 Sibgles Optimization Period, 12 weeks : Participants will begin by receiving 5 milligrams mg orally, twice a day. Each participant's dose of AG may be increased to 20 mg twice a day and then to 50 mg twice a day depending on their response to AG and tolerability. After completion of Part 2, participants who, in the opinion of the Investigator, have demonstrated clinical benefit from AG treatment will continue AG treatment in the Continued Treatment Period.
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